The drug-induced utopias of four Coney Island residents are shattered when their addictions run deep.
Ellen Burstyn
Sara Goldfarb
Jared Leto
Harry Goldfarb
Jennifer Connelly
Marion Silver
Marlon Wayans
Tyrone C. Love
Christopher McDonald
Tappy Tibbons
Louise Lasser
Ada
Marcia Jean Kurtz
Rae
Janet Sarno
Mrs. Pearlman
Suzanne Shepherd
Mrs. Scarlini
Joanne Gordon
Mrs. Ovadia
Charlotte Aronofsky
Mrs. Miles
Mark Margolis
Mr. Rabinowitz
Michael Kaycheck
Donut Cop
Jack O'Connell
Corn Dog Stand Boss
Chas Mastin
Lyle Russel
Ajay Naidu
Mailman
Sean Gullette
Arnold the Shrink
Samia Shoaib
Nurse Mall
Peter Maloney
Dr. Pill
Abraham Abraham
King Neptune
Aliya Campbell
Alice
Te'ron A. O'Neal
Young Tyrone
Denise Dowse
Tyrone's Mother
Bryan Chattoo
Brody
Eddie De Harp
Brody's Henchman Victor
Scott Franklin
Jailer (voice)
Peter Cheyenne
Sal the Geep
Brian Costello
First AD
Abraham Aronofsky
Newspaper Man on Train
James Chinlund
Space Oddity
Olga Merediz
Malin & Block Secretary
Allison Furman
Malin & Block Office Woman
Robert Dylan Cohen
Paramedic Greenhill
Ben Shenkman
Dr. Spencer
Keith David
Big Tim
Dylan Baker
Southern Doctor
Shaun O'Hagan
Ward Attendant Seto
Leland Gantt
Ward Attendant Penn
Bill Buell
Court Doctor
Jimmie Ray Weeks
Prison Guard
Gregg Bello
E.R. Doctor
Henry Stram
ECT Technician
Heather Litteer
Big Tim Party Girl
Jenny Decker
Ami Goodheart
Nina Zavarin
Stanley B. Herman
Uncle Hank
Scott Bader
Party Animal
Jim Centofanti
Scott Chait
Daniel Clarin
Ben Cohen
Eric Cohen
Brett Feinstein
Ricky Fier
John Getz
Andrew Kessler
Ross Lombardo
Carter Mansbach
Scott Miller
Todd Miller
Joshua Pollack
Craig Rallo
Geordan Reisner
Keith Scandore
David Seltzer
Chris Varvaro
Ricardo Viñas
Chad Weiner
Jesse Weissberger
Greg Weissman
Hubert Selby Jr.
Laughing Guard
Lianna Pai
Angelic Nurse
Darren Aronofsky
Visitor (uncredited)